Thieves’ Highway is set in the world of "long-haul boys" who drive by night to bring their goods to the markets of America’s cities. Ex-G.I. Nick Garcos (Richard Conte) is a tyro trucker bent on satisfaction from the man responsible for crippling his father--ruthless market operator Mike Figlia (Lee J. Cobb). Along the way, he is seduced by siren Rica (Valentina Cortesa) and drawn into the San Francisco produce racket--landing him in a web of treachery and heartbreak.