Pyrimidine derivatives possess good Therapeutic and Biological activity. This book describes literature survey and synthesis methods of some important Pyrimidine derivatives. All the new compounds characterized by C,H,N Elemental Analysis, FT-IR, 1H NMR and Mass Spectra. This book is very much useful for post gradute and research scholar in Chemistry, Pharmacy and Microbiology who are familiar with syntheis of Heterocyclic derivatives and their biological evaluation.