Sherlock Holmes opens his very first case on Nintendo Wii with this great adventure, created to make use of the console's unique features, which will see the player acting as both Sherlock Holmes and his faithful friend, Doctor Watson in order to clear up this astonishing story.

On a warm evening in May 1897, Sherlock Holmes, accompanied by Dr. Watson arrives at a party in the fabulous Sherringford Hall. It was rumoured that the host, Sir Melvyn Bomsby, a construction tycoon was to make an announcement of great importance concerning the future of his business.

At 11 PM people began to crowd around the bar in anticipation as Sir Bromsby and his chief associate Hermann Grimble took to the stage. Barely had he begun to welcome his guests when Sir Bromsby fell to the floor, a darkening red stain visible on his tuxedo right above his heart. Holmes decides not to wait for the police before beginning his investigation, but when more deaths occur, Holmes must rely on his keen sense of deduction and the support of his faithful friend, Doctor Watson, to help him solve this dark case.