The year is 1863. Paris is imbued with the spirit of revolution. A group of rogue painters,later to become known as the Impressionists, revolt against the ideals of the art establishment. One of them,Dr Paul Gachet,is also inspired to update the world of medicine ... with homeopathy. 1863, Paris, newly built by Haussmann. Avenues have superseded alleys, and cafés have sprung up where there used to be hovels. A group of talented creatives want more than just the face of the city to change. They want their stark truth to be accepted by society, and they are prepared to fight for their ideas to be heard. Dr Paul Gachet, doctor, artist and trustworthy friend to the Impressionists is one of them. He explores the spirit of substances by testing them upon himself and brings Camille Pissarro s brother back from the brink of death using one of his unlikely medicines. When he successfully treats a young prostitute at the hospital Salpêtrière who is diagnosed with insanity, he discovers that there s much more than just his integrity at stake.