In this third installment of the popular series from Robert Rodriguez that features high-tech 3-D animation woven into the images of the film with digital technology. Juni Cortez (Daryl Sabara) is ready to quit the OSS spy Agency until the President (George Clooney, in one of the film's many celebrity cameos) warns him that the evil Toymaker (Sylvester Stallone) has taken his sister Carmen (Alexa Vega) hostage in a virtual reality videogame created to take over the minds of the young people playing it. In order to rescue Carmen and save the world from the domination of the Toymaker, Juni must journey inside of the videogame and risk his own life to beat it and the various riddles and monsters designed to challenge him. Leaving his spy parents (Antonio Banderas and Carla Gugino) behind, Juni brings along his Grandfather (Ricardo Montelban) and OSS agents Cesca (Salma Hayek) and Donnagon Giggles (Mike Judge) to help him save the world. Once inside the technicolour reality Juni must conquer each level of the game while avoiding death and the ultimate videogame defeat: "game over." Rodriguez' usual brand of high-octane adventure and nonstop action is fueled by the film's 3-D animation and numerous celebrity cameos including: Steve Buscemi, Alan Cumming, Bill Paxton, and Elijah Wood.