Over the last decade Mexico has implemented a variety of policies to support business innovation. Support instruments have included direct subsidies to firms in the framework of competitive calls and R&D tax credit schemes. Specific policies have aimed at supporting public-private partnerships and technological collaboration between public research institutes and higher education institutions and enterprises. In many instances support focused on priority sectors or technology areas, but in recent years more emphasis has been placed on support to small and medium-sized enterprises and the build-up of technology transfer capacities. This report evaluates the performance of the knowledge-based sector in Mexico and provides policy recommendations for improving the financing, creation and expansion of innovative knowledge-based start-ups.