Janeway's Immunobiology is a textbook that introduces
the immune system in all its aspects to undergraduates,
and also provides a treatment of the subject that is
comprehensive enough to be useful to graduate students
interested in research, and to medical students focused
on clinical applications. The Eighth Edition has been
thoroughly revised and updated and is available in both
print and e-book formats. Janeway's Immunobiology
continues to set the standard for currency and authority
with its clear writing style and organization, uniform
art program, and scientific accuracy. It presents a
consistent point of view throughout-that of the host's
interaction with an environment containing many species
of potentially harmful microorganisms. The full-color
art program is conceptually coherent and illustrates the
processes and mechanisms underlying the concepts in the
text. The 16 chapters in this readable, accessible
textbook are organized and presented in such a way as to
help deliver a complete one-semester immunology course,
beginning with innate immunity, then moving to adaptive
immunity, and ending with applied clinical
immunology.Discussion questions are provided at the end
of Chapters 2 to 16. These questions can be used for
review, or as the basis for discussion in class or in
informal study groups. Summaries conclude each section
and each chapter. As in previous editions, a caduceus
icon in the margins indicates topics which are
correlated to Case Studies in Immunology, Sixth Edition
by Geha and Notarangelo. New in the Eighth Edition
Innate immunity has been updated and expanded and is now
presented in two separate chapters (Chapters 2 and 3),
as well as being further emphasized in the rest of the
textbook. Chapter 2 covers antimicrobial peptides and
the complement system, and Chapter 3 deals with cellular
innate receptors and cell-mediated innate immunity (e.g.
TLRs, phagocytosis, NK cells, interferon production,
innate-like lymphocytes). The section on complement has
been reworked and reconceived-explaining the lectin
pathway first-making it easier to teach by placing it
into the context of innate recognition. Evolution is now
incorporated throughout the text, helping students see
similar strategies used by different organisms.The text
and figures of Chapter 7 Signaling Through Immune System
Receptors have been revised to present a cohesive
synthesis of signaling for immunology, focusing on
improved illustration of antigen recognition signaling
and lymphocyte activation. Signaling through other
receptors is dealt with wherever appropriate throughout
the book. Updated chapter on B-cell immune responses
(Chapter 10), especially on trafficking of B cells in
peripheral lymphoid organs (e.g. lymph nodes) and the
locations at which they encounter antigen. Coverage of
mucosal immunity (Chapter 12) has been brought up to
date, including responses to the commensal microbiota
and the role of specialized dendritic cells and the
regulatory T cells in maintaining tolerance to food
antigens and commensal bacteria. Chapter 13, Failures of
Host Defense Mechanisms, has been reorganized and
revised to structure an understanding of primary
immunodeficiencies in the context of developmental
pathways. Chapter 16, Manipulation of the Immune
Response, has been heavily revised to include a greater
emphasis on clinical issues and a complete update of
immunotherapeutics and vaccines.Many new and revised
figures illustrate the processes and mechanisms
underlying the concepts presented in the text. The icons
used have been updated and expanded to incorporate a new
emphasis on signaling pathways. New references have been
added throughout the text. |
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