Guitar Hero 5 to kolejna odsłona uwielbianej przez wszystkich pozycji muzycznej. Tym razem Neversoft zupełnie przemodelował grę, co zapewnia całkiem świeże podejście do gitarowego tematu.
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3 Doors Down - "Kryptonite"
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A Perfect Circle - "Judith"
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AFI - "Medicate"
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Arctic Monkeys - "Brianstorm"
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Attack! Attack! UK - "You And Me"
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Band Of Horses - "Cigarettes, Wedding Bands"
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Beastie Boys - "Gratitude"
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Beck - "Gamma Ray"
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Billy Idol - "Dancing With Myself"
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Billy Squier - "Lonely Is The Night"
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Blink-182 - "The Rock Show"
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Blur - "Song 2"
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Bob Dylan - "All Along The Watchtower"
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Bon Jovi - "You Give Love A Bad Name"
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Brand New - "Sowing Season (Yeah)"
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The Bronx - "Six Days A Week"
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Bush - "Comedown"
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Children Of Bodom - "Done With Everything, Die For Nothing"
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Coldplay - "In My Place"
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Darker My Love - "Blue Day"
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Darkest Hour - "Demon(s)"
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David Bowie - "Fame"
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Deep Purple - "Woman From Tokyo ('99 Remix)"
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The Derek Trucks Band - "Younk Funk"
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Dire Straits - "Sultans Of Swing"
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The Duke Spirit - "Send A Little Love Token"
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Duran Duran - "Hungry Like The Wolf"
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Eagles Of Death Metal - "Wannabe In L.A."
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Elliott Smith - "L.A."
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Elton John - "Saturday Night's Alright (For Fighting)"
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Face To Face - "Disconnected"
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Garbage - "Only Happy When It Rains"
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Gorillaz - "Feel Good Inc."
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Gov't Mule - "Streamline Woman"
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Grand Funk Railroad - "We're An American Band"
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Iggy Pop - "Lust For Life (Live)"
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Iron Maiden - "2 Minutes To Midnight"
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Jeff Beck - "Scatterbrain (Live)"
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Jimmy Eat World - "Bleed American"
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Johnny Cash - "Ring Of Fire"
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John Mellencamp - "Hurts So Good"
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Kaiser Chiefs - "Never Miss A Beat"
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The Killers - "All The Pretty Faces"
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King Crimson - "21st Century Schizoid Man"
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Kings Of Leon - "Sex On Fire"
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Kiss - "Shout It Out Loud"
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Love and Rockets - "Mirror People"
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Megadeth - "Sweating Bullets"
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Motley Crue - "Looks That Kill"
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Muse - "Plug In Baby"
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My Morning Jacket - "One Big Holiday"
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Nirvana - "Lithium (Live)"
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Nirvana - "Smells Like Teen Spirit"
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No Doubt - "Ex-Girlfriend"
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Peter Frampton - "Do You Feel Like We Do? (Live)"
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The Police - "So Lonely"
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Public Enemy Featuring Zakk Wylde - "Bring the Noise 20XX"
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Queen & David Bowie - "Under Pressure"
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The Raconteurs - "Steady As She Goes"
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Queens Of The Stone Age - "Make It Wit Chu"
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Rammstein – "Du Hast"
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The Rolling Stones - "Sympathy For The Devil"
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Rose Hill Drive - "Sneak Out"
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Rush - "The Spirit Of Radio (Live)"
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Santana - "No One To Depend On (Live)"
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Scars On Broadway - "They Say"
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Screaming Trees - "Nearly Lost You"
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Smashing Pumpkins - "Bullet With Butterfly Wings"
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Sonic Youth - "Incinerate"
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Spacehog - "In The Meantime"
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Stevie Wonder - "Superstition"
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Sublime - "What I Got"
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Sunny Day Real Estate - "Seven"
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T. Rex - "20th Century Boy"
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The Sword - "Maiden, Mother & Crone"
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Thin Lizzy - "Jailbreak"
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Thrice - "Deadbolt"
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Tom Petty - "Runnin' Down A Dream"
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Tom Petty & The Heartbreakers - "American Girl"
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Vampire Weekend - "A-Punk"
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Weezer - "Why Bother?"
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The White Stripes - "Blue Orchid"
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TV On The Radio - "Wolf Like Me"
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Wild Cherry - "Play That Funky Music"
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Wolfmother - "Back Round"