Discover how advances in mass spectrometry are
fueling new discoveries across a broad range of research
areas Electrospray and MALDI Mass Spectrometry brings
both veteran practitioners and beginning scientists up
to date with the most recent trends and findings in
electrospray ionization and matrix–assisted laser
desorption/ionization (MALDI) mass spectrometry. In
particular, this Second Edition highlights how advances
in electrospray and MALDI mass spectrometry are
supporting important discoveries in new and emerging
fields such as proteomics and metabolomics as well as in
traditional areas of chemistry and physics research.
Electrospray AND MALDI Mass Spectrometry, SECOND EDITION
is divided into five parts: Part A, Fundamentals of ES,
explains the fundamental phenomena underlying the
electrospray process, including selectivity in
ionization and inherent electrochemistry, and concludes
with a chapter offering a comparative inventory of
source hardware Part B, Fundamentals of MALDI, confronts
ionization mechanisms, instrument development, and
matrix selection, and includes a final chapter that
explores the special application of MALDI to obtain
two–dimensional images of spatial distributions of
compounds on surfaces Part C, ES and MALDI Coupling to
Mass Spectrometry Instrumentation, examines the coupling
of these ionization techniques to various mass
analyzers, including quadrupole ion trap,
time–of–flight, Fourier transform ion cyclotron
resonance, and ion mobility mass spectrometers Part D,
Practical Aspects of ES and MALDI, investigates
analytical issues including quantification, charge–state
distributions, noncovalent interactions in solution that
are preserved as gas–phase ions, and various means of
ion excitation in preparation for tandem mass
spectrometry, and offers a guide to the interpretation
of even–electron mass spectra Part E, Biological
Applications of ES and MALDI, examines the role of mass
spectrometry in such areas as peptide and protein
characterization, carbohydrate analysis, lipid analysis,
and drug discovery Written by a team of leading experts,
the book not only provides a critical review of the
literature, but also presents key concepts in tutorial
fashion to help readers take full advantage of the
latest technological breakthroughs and applications. As
a result, Electrospray and MALDI Mass Spectrometry will
help researchers fully leverage the power of
electrospray and MALDI mass spectrometry. The judicious
compartmentalization of chapters, and the pedagogic
presentation style throughout, render the book highly
suitable for use as a text for graduate–level courses in
advanced mass spectrometry.
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