After twenty years of searching, Celty, the headless Black Rider, has at last found her missing head - bobbing through the streets of Ikebukuro on someone else's neck! Though Celty pursues, the girl escapes on the arm of Mikado Ryuugamine, taking refuge in Mikado's apratment. But Celty isn't the only one whoe's after the scarred girl. Seiji's love for the head and his sister's equally passionate desire to keep his obsession at bay brings the full power of Yagiri Pharmaceuticals bearing down on Mikado and his friends!