Former elite agent Kitty Galore plans to unleash a diabolical device designed to not only bring her canine enemies to heel but also to take down her former kitty comrades and make the world her scratching post. Cats and dogs must now join forces for the first time ever to prevent a global cat-astrophe. This fun adventure features the voice talent of Christina Applegate, Michael Clarke Duncan, Neil Patrick Harris, Sean Hayes, James Marsden, Bette Midler and Nick Nolte and stars Chris O'Donnell and Jack McBrayer.