Nietzsche continues to occupy a special place - not only for a broad range of academics but also for members of a wider public, who find some of their most pressing existential concerns addressed in his works. Central among these concerns is the question of the meaning of a life characterized by inescapable suffering, at a time when the traditional responses inspired by Christianity are increasingly losing their credibility. While most recent studies of Nietzsche's works have lost sight of this fundamental issue, Bernard Reginster brings it sharply into focus.