Sean Penn and Benecio Del Toro, two of the most gripping actors around, play wildly different men linked through a grieving woman (Naomi Watts) in 21 Grams. Del Toro delves deep into the role of an ex-con turned born-again Christian, a deeply conflicted man struggling to set right a terrible accident, even at the expense of his family. Penn captures a cynical, philandering professor in dire need of a heart transplant, which he gets from the death of Watts' husband. 21 Grams slips back in forth in time, creating an intricate emotional web out of the past and the present that slowly draws these three together; the result is remarkably fluid and compelling. The movie overreaches for metaphors towards the end, but that doesn't erase the power of the deeply felt performances. --Bret Fetzer