This long–awaited sequel to "Dead Ends and Detours" retains the proven concept while featuring over 20 new case studies of failed strategies and their (successful) solutions in natural product total synthesis. Furthermore, computational models are used to discuss the problem in much more detail and to provide readers with additional information not found in the primary literature. The topics include classic synthetic reactions, metal–mediated coupling reactions, metathesis, asymmetric catalysis, and the importance of protecting and activating groups. As a result, both graduate students in organic chemistry and advanced researchers will benefit from the knowledge derived from the step–by–step analysis of mistakes made in the past and, thus be able to improve their own chemical reaction planning. With its coverage of the most commonly applied reaction types, the book perfectly complements its predecessor, which focuses on general aspects, thus making it attractive to former and prospective readers.