Day to day numbers of newer drugs and their formulations either in single or in combined dosage forms are marketed.Combination of ciprofloxacin and metronidazole is one of new combination used in crohn’s disease. This combination is not official in any pharmacopoeia; hence official method of analysis is not available.So it was thought of interest to develop simple, sensitive, specific, accurate, precise and economical spectroscopic as well as chromatographic analytical methods for the estimation of these two drugs in combined dosage forms. Nikita Patel, For this work I would like to express my love and gratitude to my parents. Their blessings always inspire me to work hard and to overcome all the difficulties throughout my life. It gives me an immense pleasure to dedicate my research work at their feet without whose blessings and vision I would not have been able to achieve this task.I thankful to Dr.Arun.M.Prajapati for his profound guidance and sharing of knowledge. At last but not least I owe a special word of thanks to Nishit Patel who inspire me for this work.Thank you very much to the God for blessing hands over me.